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目的评估长沙市男男性接触者艾滋病、丙型肝炎、梅毒的现患率,了解男男性接触者的人口学基本特征。为对该目标人群实施有效的行为干预措施,控制艾滋病病毒(HIV)、丙型肝炎病毒(HCV)、梅毒螺旋体(TP)的传播提供科学依据。方法以常规检测信息为基础寻找种子,采用分类滚雪球方法招募521名研究对象。通过统一格式的问卷调查被访者人口学、行为学信息。采用酶联免疫吸附试验(ELISA)进行HIV抗体初筛检测,初筛阳性样本采用免疫印迹法(WB)进行确证检测。采用ELISA检测丙型肝炎抗体。采用ELISA(IgG)、快速血浆反应素环状卡片试验(RPR)、梅毒螺旋体明胶颗粒凝集试验(TPPA)检测梅毒螺旋体。运用SPSS16.0统计软件包进行数据录入和统计学分析。结果共招募521名男男性接触者作为研究对象,其中问卷和采集的样本均完整和符合要求的研究对象507名,平均年龄(25.84±5.4)岁。共检出HIV抗体阳性(22/507)例,确证(22/507)例,感染率4.33%;梅毒血清学阳性(127/507)例,感染率25.05%;HCV抗体阳性(3/507)例(其中2例为吸毒者,1例为非吸毒者),感染率0.59%。结论男男性接触者性行为特征导致梅毒、HIV感染风险较高,需要采取有针对性的综合防治措施加以控制。HCV感染率相对较低,但其有与HIV相似的传播方式,所以对HCV的综合防治不容忽视。
Objective To evaluate the prevalence of HIV, hepatitis C and syphilis in MSM in Changsha and to understand the basic demographic characteristics of MSM. To provide a scientific basis for the implementation of effective behavioral interventions for this target population and for the control of the spread of HIV, HCV and Treponema pallidum (TP). Methods Based on routine test information, 521 subjects were recruited using the classified snowball method. Respondents demographic and behavioral information through a uniform format of the questionnaire. Enzyme-linked immunosorbent assay (ELISA) was used to detect HIV antibody. Positive samples were screened by Western blot. Hepatitis C antibody was detected by ELISA. Treponema pallidum was detected by ELISA (ELISA), Rapid Plasma Cardin Receptor Card Reagent Card (RPR) and Treponema Pallidum Gelatin Granule Agglutination Test (TPPA). Using SPSS16.0 statistical software package for data entry and statistical analysis. Results A total of 521 MSM were enrolled in the study. Among them, 507 questionnaires and samples were collected and completed, with an average age of 25.84 ± 5.4 years. HIV positive (22/507) cases were confirmed (22/507), the infection rate was 4.33%; the syphilis serological (127/507) cases were positive, the infection rate was 25.05%; HCV antibody positive (3/507) (2 cases were drug users and 1 case was non-drug users), the infection rate was 0.59%. Conclusions The characteristics of sexual behavior of MSM lead to syphilis. HIV infection is at a high risk and need to be controlled by targeted and comprehensive prevention and control measures. HCV infection rate is relatively low, but it has a similar mode of transmission of HIV, so the integrated control of HCV can not be ignored.