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The Chinese herb Shuyusan,whose main constituent is jasminoidin,has been shown to protect SH-SY5Y cells against corticosterone-induced damage.SH-SY5Y cells injured by 400 μmol/L corticosterone were treated with 5 and 30 μg/mL Shuyusan-containing serum.Results revealed that Shuyusan-containing serum elevated the survival rate of SH-SY5Y cells,reduced Bax expression,increased Bcl-2 expression,markedly elevated brain-derived neurotrophic factor mRNA expression,and blocked cell apoptosis.Moreover,the effect of high-dose (30 μg/mL) Shuyusan-containing serum was more remarkable.Therefore,Shuyusan-containing serum appears to protect SH-SY5Y cells against corticosterone-induced impairment by adjusting the expression of apoptosis-associated proteins and brain-derived neurotrophic factor.Moreover,high-dose Shuyusan-containing serum has a protective effect on high-dose corticosterone-induced impairment.
The Chinese herb Shuyusan, whose main constituent is jasminoidin, has been shown to protect SH-SY5Y cells against corticosterone-induced damage. SH-SY5Y cells were injured by 400 μmol / L corticosterone were treated with 5 and 30 μg / mL Shuyusan-containing serum . Results caused that Shuyusan-containing serum elevated the survival rate of SH-SY5Y cells, reduced Bax expression, increased Bcl-2 expression, markedly elevated brain-derived neurotrophic factor mRNA expression, and blocked cell apoptosis. Moreover, the effect of high- Shuyusan-containing serum was more remarkable. Beforefore, Shuyusan-containing serum appeared to protect SH-SY5Y cells against corticosterone-induced impairment by adjusting the expression of apoptosis-associated proteins and brain-derived neurotrophic factor. Moreover , high-dose Shuyusan-containing serum has a protective effect on high-dose corticosterone-induced impairment.