弥漫性血管内凝血患儿血浆D-二聚体的检测及意义

• 作 者: 徐大庆 康绍婵 白海霞 陈士杰
• 机 构: 中国医科大学第二临床学院
• 出 处: 小儿急救医学
• 发表日期: 1999年02期
• 关键词: 二聚体 双抗体夹心 特异性指标 乳胶凝集法 继发性纤溶 酶联免疫吸附 温育 纤溶酶活性 凝血酶原 特异性标志物

目的研究弥漫性血管内凝血（ＤＩＣ）患儿血浆Ｄ二聚体水平对ＤＩＣ的诊断价值。方法采用双抗体夹心ＥＬＩＳＡ法及乳胶凝集法（Ｌａｔｅｘ）法对４２例ＤＩＣ患儿血浆Ｄ二聚体进行检测，用ｔ检验进行分析。结果ＤＩＣ患儿血浆Ｄ二聚体水平明显高于对照组，差异非常显著（Ｐ＜００１）。结论血浆Ｄ二聚体是诊断ＤＩＣ的早期、特异性指标

Objective To study the diagnostic value of D-dimer in children with diffuse intravascular coagulation (DIC). Methods Plasma DDimers in 42 DIC children were detected by double antibody sandwich ELISA and latex agglutination (Latex) method and analyzed by t test. Results The level of D-dimer in children with DIC was significantly higher than that in the control group (P <001). Conclusion Plasma D-dimer is an early and specific indicator of DIC diagnosis