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为了全面了解肥胖与认知功能的关系及其潜在机制,采用文献资料法在中外数据库搜索了近10年发表的18篇外文文献和5篇中文文献,对其进行归纳和分析,并从肥胖与认知功能的关系和潜在机制2个方面对其进行探讨。结果发现:关于肥胖与认知功能的关系,其研究结论并不统一,但大部分研究表明肥胖会导致认知功能下降;肥胖引发的炎症和胰岛素、多巴胺含量减少等生理变化以及与认知功能相关脑区萎缩的脑结构变化是肥胖导致认知功能下降的主要潜在机制。
In order to fully understand the relationship between obesity and cognitive function and its underlying mechanism, 18 literature and 5 Chinese literatures published in the recent 10 years were searched by using the literature method in Chinese and foreign databases, and summarized and analyzed from obesity and Cognitive function of the relationship between the two mechanisms and potential aspects of its discussion. The results showed that: the relationship between obesity and cognitive function, the conclusions of the study is not uniform, but most studies have shown that obesity will lead to cognitive decline; obesity-induced inflammation and insulin, dopamine and other physiological changes and cognitive function Cerebral structural changes associated with brain atrophy are major underlying mechanisms underlying obesity leading to cognitive decline.