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目的研究妊娠合并麻疹的临床特点、治疗方法及妊娠结局。方法对首都医科大学附属北京地坛医院2008年1月至2014年12月收治的30例妊娠合并麻疹的临床表现、实验室检查、治疗情况及妊娠结局进行回顾性分析。结果 30例患者均出现典型皮疹、高热;患者外周血白细胞计数多数正常、中性粒细胞百分比多数升高,淋巴细胞百分比降低;C-反应蛋白(C-reactionprotein,CRP)、降钙素原及血沉均不同程度升高;乳酸脱氢酶、肌酸激酶不同程度升高;26例患者抗麻疹抗体阳性,存活新生儿23例,新生儿未发现畸形,2例检测发现抗麻疹抗体阳性;2例进行胎盘病理,1例进行尸检。结论妊娠合并麻疹病情重、对母儿危害大,及时诊断和治疗可以痊愈,适时终止妊娠,可以改善母儿预后。
Objective To study the clinical features, treatment and pregnancy outcome of measles complicated with pregnancy. Methods The clinical manifestations, laboratory tests, treatment and pregnancy outcomes of 30 pregnant women with measles in pregnancy from January 2008 to December 2014 in Beijing Ditan Hospital, Capital Medical University were retrospectively analyzed. Results All the 30 patients showed typical rash and high fever. Most patients had normal peripheral blood leukocyte count, most of the neutrophils percentage increased and lymphocyte percentage decreased. C-reaction protein (C-reactive protein), procalcitonin and ESR and creatine kinase increased to varying degrees. Twenty-six patients were positive for anti-measles antibody, 23 were surviving newborns, and no abnormality was found in newborns. Anti-measles antibody was found in 2 cases. 2 Cases of placental pathology, 1 case of autopsy. Conclusions Pregnancy complicated with measles is serious and harmful to mother and child. It can be cured and diagnosed in time. Pregnancy termination can be timely and the prognosis of mother and child can be improved.