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目的观察坤泰胶囊对女性子宫切除术后围绝经期症状的影响。方法收集125例因子宫良性病变而行子宫全切术的病例资料,分为治疗组和对照组。治疗组于术后1个月开始口服坤泰胶囊,每次4粒,3次/d;对照组术后一个月开始口服安慰剂,每次4粒,3次/d;两组术后避免使用任何影响卵巢功能的药物。服药3个月后对患者进行Kupperman评分,观察患者出现围绝经期的症状及时间,分别于服药前及服药3个月检测患者血清促卵泡激素(FSH)、雌二醇(E2)水平。结果服药3个月后,治疗组围绝经期综合症的发病率低于对照组(P<0.05),雌激素水平治疗组高于对照组,差异有统计学意义(P<0.05)。结论坤泰胶囊可有效改善子宫切除术患者围绝经期症状,值得临床推广。
Objective To observe the effect of Kuntai capsule on perimenopausal symptoms after female hysterectomy. Methods A total of 125 cases of benign uterine lesions were collected and hysterectomy cases were divided into treatment group and control group. The patients in the treatment group started oral administration of Kuntai capsule once a month for 4 times a day for 3 times / d, and the control group took oral placebo once a month for 4 times a day for 3 times / d. Use any drugs that affect ovarian function. Patients were treated with Kupperman score 3 months after treatment. The symptoms and time of perimenopausal period were observed. Serum follicle stimulating hormone (FSH) and estradiol (E2) levels were measured before treatment and 3 months after taking the medicine. Results The incidence of perimenopausal syndrome in the treatment group was lower than that in the control group (P <0.05) after 3 months of treatment. The level of estrogen in the treatment group was higher than that in the control group (P <0.05). Conclusion Kun Tai Capsule can effectively improve the symptoms of perimenopausal patients with hysterectomy, it is worth clinical promotion.