论文部分内容阅读
目的观察消痰和胃方对胃癌前病变大鼠胃黏膜病理状态的影响。方法清洁级Wistar雄性大鼠,空白对照组和模型组,模型组采用以化学干预为主的多因素造模方法,共32周。模型组再分为模型对照组、维酶素组、消痰和胃方组,分别予生理盐水、维酶素混悬液、消痰和胃方浸膏(由柴胡、制半夏、桂枝、细辛、黄连、炒枳壳、白芍、炙甘草等药物组成)灌胃,干预6周后观察胃黏膜病理状态的差异。结果与维酶素组比较,消痰和胃组能增加胃癌前病变大鼠模型质量(P<0.05),有效逆转胃癌前病变胃黏膜病理状态(P<0.05)。结论消痰和胃方改善胃癌前病变大鼠整体情况与逆转胃癌前病变大鼠胃黏膜组织病理状态相关。
Objective To observe the effects of Phlegm-Resuscitation and Stomach-Recipe on the pathological state of gastric mucosa in precancerous lesions of rats. Methods Wistar male rats, blank control group and model group were randomly divided into two groups. The model group was predominated by chemical intervention for multiple factors modeling for 32 weeks. The model group was subdivided into model control group, Vitexin group, Xiaotan and Weifang group, respectively, with normal saline, Vitexin suspension, Xiaotan and Weifang extract (made of Radix Bupleuri, Pinellia ternata, Branches, Asarum, Coptis, fried Citrus aurantium, white peony root, Zhigancao and other drugs) by intragastric administration, after 6 weeks of intervention to observe the differences in the pathological state of gastric mucosa. Results Compared with Vitexin group, Xiaotan and stomach group could increase the quality of rats with gastric precancerous lesions (P <0.05) and effectively reverse the pathological changes of gastric mucosa (P <0.05). Conclusion Phlegm and Stomach improve gastric precancerous lesions in rats overall situation and reverse gastric precancerous lesions of gastric mucosa histopathological correlation.