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  5. Drug discovery based on the structure of FKBP12: Design, synthesis and evaluation of L-1,4-thiazane-

Drug discovery based on the structure of FKBP12: Design, synthesis and evaluation of L-1,4-thiazane-

来源 :中国科学：化学英文版 | 被引量 : 0次 | 上传用户：oppoyy
【摘 要】
：
By choosing neuroimmunophilin FKBP12 as a therapeutical target, we have attempted to discover a new structural drug for treating neurodegenerative disease. This
【作 者】
：
AiHua Nie (1)  JunHai Xiao (1 
【机 构】
：
1.BeijingInstituteofPharmacologyandToxicology
【出 处】
：
中国科学：化学英文版
【发表日期】
：
2007年3期
【关键词】
：
FKBP12 L-1 4-thiazane-3-carboxylic acid derivatives DESIGN SYNTHESIS NEUROTROPHI 
【基金项目】
：
Supported by the National Basic Research Program of China (Grant No. G1998051107),Hi-tech Research and Development Program of China (Grant No. 2002AA233051)
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By choosing neuroimmunophilin FKBP12 as a therapeutical target, we have attempted to discover a new structural drug for treating neurodegenerative disease. This drug should possess neurotrophic activity and not affect the immune system. Based on the cryst
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