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目的:了解非胰岛素依赖型糖尿病(NIDDM)病情与其大血管合并症(MaVC)的关系。方法:135例NIDDM根据合并冠心病、脑动脉硬化、高血压3种合并症的有无或多少分成4组:1无合并症组(N)组;2一种合并症组(组);3两种合并症组(组);43种合并症组(组)。观察口服葡萄糖耐量试验(OGTT)、胰岛素释放试验(IRT)及血生化指标。结果:1NIDDMMaVC的总发病率为44%,男性比女性倾向于发生MaVC(P=0.0009),、、组的年龄均比N组显著增高(P<0.01),组比组、组比组年龄有不显著增高。仅组病程比N组显著增高;2各组OGTT数据与MaVC发生或多少的关系无规律性;3、、组的峰值胰岛素均比N组高(P<0.01),且、组比组高(P<0.05),组比组显著增高。结论:男性NIDDM比女性更易发生MaVC,年龄增大、血胰岛素相对升高不仅与MaVC的发生有关,而且与MaVC的多少有正关联:MaVC的发生与多少与病程和血糖水平无明显关系
Objective: To investigate the relationship between non-insulin dependent diabetes mellitus (NIDDM) and its macrovascular complications (MaVC). Methods: One hundred and thirty-five patients with NIDDM were divided into 4 groups based on the presence or absence of 3 complications including coronary heart disease, cerebral arteriosclerosis and hypertension: 1 without complications (N), 2 with complications (group), 3 Two kinds of complications group (group); 43 kinds of complications group (group). The oral glucose tolerance test (OGTT), insulin release test (IRT) and blood biochemistry indexes were observed. Results: The overall incidence of 1NIDDMMaVC was 44%, and males tended to have MaVC more than females (P = 0.0009). The age of the group was significantly higher than that of the N group (P <0.01) Not significantly higher. Only the course of the disease was significantly higher than that of the N group; 2 the relationship between OGTT data and the incidence of MaVC or irregularity in each group was irregular; 3, the peak insulin of the group was higher than that of the N group (P <0.01) P <0.05), the group than the group was significantly higher. CONCLUSIONS: Males with NIDDM are more likely to develop MaVC than those with females, and their age is increased. The relative increase of blood insulin is not only related to the occurrence of MaVC but also positively correlated with the number of MaVC: There is no significant correlation between the incidence and the number of MaVC and the course of disease and blood glucose level