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本文对61例经病理证实的CAH患者肝穿刺标本,应用电镜观察,对以下三方面作了研究与讨论。1.肝组织内浸润的淋巴细胞胞质呈伪足状突起攻击肝细胞,是引起肝细胞坏死的直接原因,是细胞免疫反应在超微结构形态学上的表现,是CAH活动的标志。2.狄氏间隙内贮脂细胞增生,转化成为纤维细胞,引起狄氏间隙纤维化和血窦毛细血管化,导致肝微循环障碍,是CAH慢性化的一个重要因素。3.坏死区边缘卵圆细胞增生活跃,向肝细胞方向分化,是重度CAH患者AFP值升高和受损肝细胞得以修复的物质基础。
In this paper, 61 cases of pathologically confirmed CAH liver biopsy specimens, the application of electron microscopy, the following three aspects were studied and discussed. 1. Liver tissue infiltration of lymphocyte cytoplasm was pseudopod-like protrusions attacking liver cells, is the direct cause of liver cell necrosis is the cellular immune response in the ultrastructure of the morphological performance of CAH activity is a sign. 2. Dick’s gap in the storage of fat cells, transformed into fibroblasts, causing the gap fibrosis and sinusoidal sinusoids, leading to liver microcirculation, is an important factor in CAH chronicity. The marginal oval cells in the necrotic area proliferate actively and differentiate into hepatocytes, which is the material basis for the elevated AFP value and the repair of damaged hepatocytes in severe CAH patients.