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用氯喹灌胃大鼠可致生精障碍,电镜下发现服氯喹组最早有Sertoli细胞溶酶体变化。形态计量发现细胞溶酶体数目略减少(P>0.05),体积增大(P<0.01)。作者还讨论了Sertoli细胞溶酶体的变化对精子发生的意义。
Oral administration of chloroquine can cause dysgeusia, electron microscopy found that serotonin group had the earliest Sertoli cell lysosome changes. Morphometry showed a slight decrease in the number of lysosomes (P> 0.05), volume (P <0.01). The authors also discuss the significance of changes in Sertoli cell lysosomes on spermatogenesis.