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目的 :探讨孕早期胎儿染色体异常的产前筛查方案。方法 :采用时间分辨荧光免疫法 (TRFIA)对孕 11 14周的 2 739例孕妇血清中的人绒毛促性腺激素β亚单位 (β hCG)、妊娠相关血浆蛋白A(PAPP A)进行检测 ,同时利用腹式或阴道B型超声波测量胎儿颈部半透明膜 (NT)厚度 ,筛查出 2 2例染色体异常胎儿 (通过羊水细胞染色体核型分析明确诊断 ) ,比较分析 2 2例染色体异常胎儿与 870例对照组三种标记物水平。结果 :病例组NT和 β hCG值明显较对照组高 ,PAPP A值明显比对照组低 ,差异有统计学意义 ,三项指标联合筛查 ,胎儿染色体异常检出率为 91.6 7% ,假阳性率为 11.16 %。结论 :孕早期NT +β hCG +PAPP A三联筛查方案对孕早期产前筛查胎儿染色体异常有较好的实用价值。
Objective: To investigate the prenatal screening program of fetal chromosomal abnormalities in early pregnancy. Methods: Human chorionic gonadotropin β subunit (β hCG) and pregnancy-associated plasma protein A (PAPP A) were detected in 2 739 pregnant women at 1114 weeks of gestation by time-resolved fluorescence immunoassay (TRFIA) Fetal neck translucent membrane (NT) thickness was measured by abdominal or vaginal ultrasound B, and 22 fetuses with chromosomal abnormality were identified (confirmed by karyotype analysis of amniotic fluid cells), and 22 fetuses with chromosomal abnormalities 870 control group three markers level. Results: The values of NT and β hCG in case group were significantly higher than those in control group. The PAPP A value was significantly lower than that in control group. The difference was statistically significant. The combined detection of three indicators showed that the detection rate of fetal chromosomal abnormality was 91.6 7% The rate was 11.16%. Conclusion: The trimester screening program of NT + β hCG + PAPP A in early pregnancy has good practical value in prenatal screening for fetal chromosomal abnormalities in early pregnancy.