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采用随机分组、双盲、交叉、对照研究观察国产果糖二磷酸钠(FDP)对冠心病心力衰竭患者的血流动力学参数的影响,结果显示,对心力衰竭患者,FDP可使心排血量(CO)、每搏量(SV)、心排指数(CI)和每搏指数(SI)明显上升,而对平均右心房压(MRAP)、平均肺动脉压(MPAP)、肺毛细血管楔嵌压(PCWP)、心率、动脉收缩压和舒张庄无明显影响,本研究结果表明,FDP作为一种重要的细胞内中间代谢供能物质,静脉滴注后可在一定程度上改善充血性心力衰竭患者的心脏功能。
A randomized, double-blind, crossover, and controlled study was conducted to investigate the effect of domestic FDP on hemodynamic parameters in patients with heart failure and coronary heart disease. The results showed that for patients with heart failure, FDP can make cardiac output (CO), stroke volume (SV), cardioverter index (CI) and stroke index (SI) were significantly increased, while mean right atrial pressure (MRAP), mean pulmonary arterial pressure (MPAP), pulmonary capillary wedge pressure (PCWP), heart rate, arterial systolic pressure and diastolic blood pressure. The results of this study indicate that FDP, as an important intracellular metabolizable energy source, can improve the patients with congestive heart failure to a certain extent after intravenous drip Heart function.