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钙拮抗剂异搏停和抗心律失常药奎尼丁同地高辛在药代动力学的相互作用,能升高血浆地高辛浓度和增强对心脏的作用。本文作者研究了另一些钙拮抗剂和抗心律失常药与地高辛的相互作用。方法:给36例健康男性受试者在6周研究期口服地高辛0.125毫克,一日三次为基础治疗,随机分为3组,每天服地高辛的同时,按随机顺序每2周一个疗程,第1组随机顺序为异搏停80毫克、心痛定10毫克和安慰剂;第2组:异搏停
Calcium antagonist verapamil and anti-arrhythmic drugs quinidine and digoxin in the pharmacokinetic interaction, can increase plasma digoxin concentration and enhance the role of the heart. The authors studied the interaction of other calcium antagonists and antiarrhythmic drugs with digoxin. Methods: Thirty-six healthy male subjects were treated with digoxin 0.125 mg for three weeks on a 6-week study period. They were randomly divided into 3 groups. Each group received digoxin at the same time, every 2 weeks in random order , The first group randomized to 80 mg of verapamil, nifedipine 10 mg and placebo; Group 2: Verapamil