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目的分析系统性红斑狼疮(SLE)患者结核菌感染的临床表现、特点以及相关危险因素。方法回顾分析了37例SLE结核感染住院患者和65例随机抽取的SLE对照组患者的临床资料,所有患者均有完整的病史、体格检查、实验室等辅助检查的资料。结果在37例SLE结核感染患者中,肺结核13例(35%),肺结核合并其他部位结核者7例,肺外结核17例。与对照组相比,结核感染组的日平均激素的剂量和细胞毒药物使用较高,在两组之间差异有统计学意义,而性别、年龄、病程、白蛋白/球蛋白、补体和激素冲击治疗等方面,两组间差异无统计学意义。讨论SLE患者发生肺外结核感染的机会较大,且日平均激素的剂量和细胞毒药物是SLE患者发生结核感染的危险因素。
Objective To analyze the clinical manifestations, characteristics and related risk factors of tuberculosis infection in patients with systemic lupus erythematosus (SLE). Methods The clinical data of 37 patients with SLE TB infection and 65 patients with SLE control group were retrospectively analyzed. All patients had complete history, physical examination and laboratory tests. Results Among the 37 cases of SLE tuberculosis infection, 13 cases (35%) were tuberculosis, 7 cases were tuberculosis combined with tuberculosis in other parts, and 17 cases were extrapulmonary tuberculosis. Compared with the control group, the dose of daily average hormone and the use of cytotoxic drugs in tuberculosis infection group were higher, and the difference was statistically significant between the two groups, while the gender, age, course of disease, albumin / globulin, complement and hormone Impact treatment, no significant difference between the two groups. Discussion SLE patients have a greater chance of developing extrapulmonary tuberculosis infection, and the average daily dose of hormone and cytotoxic drugs are SLE patients with tuberculosis infection risk factors.