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目的 :了解内皮素、一氧化氮在妊高征发病中的作用。方法 :放射免疫分析法检测了39例妊高征患者、28例正常晚孕妇女产前及产后血浆ET的含量 ,同时采用Greiss法测定亚硝酸盐及硝酸盐以间接测定NO含量。结果 :妊高征患者产前ET较正常妊娠组明显升高 ,NO则明显下降(均 p<0.01) ,且与妊高征病情程度有一定关系 ,产后逐渐恢复正常。结论 :妊高征患者血管内皮细胞存在内分泌功能紊乱 ,ET合成释放增加 ,NO释放减少 ,以及两者反馈调控失衡在妊高征发病中具有重要意义。
Objective: To understand the role of endothelin and nitric oxide in the pathogenesis of PIH. Methods: Radioimmunoassay was used to detect plasma ET levels in 39 PIH patients and 28 normal pregnant women before and after delivery. Nitrite and nitrate were measured by Greiss method to determine NO content indirectly. Results: Prenatal ET in preeclampsia patients was significantly higher than that in normal pregnant women, and NO was significantly decreased (all p <0.01). The prenatal ET was related to the severity of PIH and returned to normal after birth. CONCLUSION: Endothelial dysfunction, increased release of ET synthesis, decreased NO release, and imbalance of feedback regulation between the two are important in the pathogenesis of PIH.