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目的:观察不同抗凝治疗方案对产褥期脑静脉及静脉窦血栓形成(CVST)的疗效。方法:选择我院及玉林市第三人民医院2011年4月~2015年6月收治的60例产褥期CVST患者为研究对象,随机分为A组(普通肝素组)和B组(低分子肝素组)各30例,观察比较两组临床疗效及预后。结果:A组总有效率96.67%与B组总有效率93.33%相近,A组腰穿复查颅内压平均降低(72±12)mm H2O与B组降低(68±8)mm H2O相近(P>0.05)。两组不良反应发生率及血栓再通率差异均无统计学意义(P>0.05)。结论:普通肝素与低分子肝素对产褥期CVST的抗凝治疗效果相近。
Objective: To observe the curative effect of different anticoagulant therapy on puerperal cerebral venous and venous sinus thrombosis (CVST). Methods: Sixty patients with CVST in puerperium admitted from April 2011 to June 2015 in our hospital and Yulin Third People ’s Hospital were randomly divided into A group (unfractionated heparin group) and B group (low molecular weight heparin group ), 30 cases each. The clinical curative effect and prognosis of the two groups were observed and compared. Results: The total effective rate in group A was 96.67%, which was similar to that in group B (93.33%). The average intracranial pressure (72 ± 12) mm H2O in group A was lower than that in group B (68 ± 8) mm H2O > 0.05). There was no significant difference in incidence of adverse reactions and thrombosis between the two groups (P> 0.05). Conclusion: The effects of unfractionated heparin and low molecular weight heparin on CVST anticoagulation in puerperium are similar.