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目的:探讨神经干细胞移植术在治疗痉挛性脑性瘫痪的应用价值。方法33例痉挛性脑性瘫痪患儿,均行靶点刺激加神经干细胞移植手术,靶点为内囊前肢。对病例行术前,术后及半年均表面肌电图检查,并采用当前国际上通用的残疾评价方法——粗大运动评估量表(Gross motor function measure GMFM)及Berg平衡量表(Berg Balance Scale,BBS)进行评估。结果术后表面肌电图复查158组肌肉肌电,改善及显著改善为80组,术后半年与术后3天50组比较,改善及显著改善为10组。术后与术前GFMF(粗大运动评估)比较,T=10.317,P<0.05,具有统计学意义,术后患者粗大运动较术前改善。术后与术前Berg(平衡量表)评估比较,T=6.44,P<0.05,具有统计学意义,术后患者平衡力较术前改善。结论神经干细胞移植可以一定程度地改善脑瘫患者的后遗症,可提高脑瘫患者的运动功能和生活质量。
Objective: To investigate the value of neural stem cell transplantation in the treatment of spastic cerebral palsy. Methods Thirty-three children with spastic cerebral palsy were treated with targeted stimulation and neural stem cell transplantation, targeting the forelimb of internal capsule. The surface electromyography (EMG) was performed before, during and after the operation in six months. The current international common disability assessment method - Gross motor function measure (GMFM) and Berg Balance Scale (Berg Balance Scale) , BBS). Results The myoelectric changes of 158 groups were improved and significantly improved to 80 groups after EMG examination. The improvement and improvement were significantly improved to 10 groups in six months after operation and in 50 days after operation. Postoperative and preoperative GFMF (gross motor evaluation), T = 10.317, P <0.05, with statistical significance, postoperative patients with coarse movement improved compared with preoperative. Postoperative and preoperative Berg (balance scale) evaluation, T = 6.44, P <0.05, with statistical significance, postoperative balance of patients improved compared with the preoperative. Conclusion Neural stem cell transplantation can improve the sequelae of cerebral palsy patients to a certain degree and improve the motor function and quality of life in patients with cerebral palsy.