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目的:探讨Beclin-1蛋白在子宫平滑肌肉瘤中的表达情况及其临床意义。方法:通过免疫组化SP法染色检测20例正常子宫组织、20例子宫平滑肌瘤和40例子宫平滑肌肉瘤中Beclin-1的表达情况,并结合临床病理因素进行分析。结果:Beclin-1在子宫正常组织和平滑肌瘤中表达率均为100.0%,明显高于子宫平滑肌肉瘤组织中的表达率67.5%,差异有统计学意义(P<0.05),而且beclin-1表达情况与子宫平滑肌肉瘤病理学因素显著相关(P<0.05)。结论:Beclin-1的表达水平可能与疾病的发生、发展和预后有关,而且对于子宫平滑肌肉瘤的治疗有一定的指导意义。
Objective: To investigate the expression of Beclin-1 protein in uterine leiomyosarcoma and its clinical significance. Methods: The expression of Beclin-1 in 20 cases of normal uterine tissue, 20 cases of uterine leiomyoma and 40 cases of uterine leiomyosarcoma was detected by immunohistochemical SP method and analyzed with clinicopathological factors. Results: The expression rates of Beclin-1 in normal uterus and leiomyoma were 100.0%, significantly higher than those in uterine leiomyosarcoma 67.5%, the difference was statistically significant (P <0.05), and Beclin-1 The expression was significantly associated with pathological factors of uterine leiomyosarcoma (P <0.05). Conclusion: The expression level of Beclin-1 may be related to the occurrence, development and prognosis of the disease, and it may be of guiding significance for the treatment of uterine leiomyosarcoma.