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呼吸道合胞病毒(简称RSV)是独特的呼吸道病原。由RSV引起的严重疾病的最高发病率是在婴儿出生后的头几个月,该时经胎盘获得的循环抗体很易被发现。在成人和儿童的感染中常伴有支气管痉挛,有人提示RSV特异性免疫机制可能在感染的病因方面起作用。虽然由RSV引起的严重疾病可伴有或不伴有特异性抗体,但在RSV感染中有关细胞免疫作用的资料目前很少。本研究的目的是测定细胞免疫对于RSV所致疾病的类型及严重性所形成的影响。结果指出T淋巴细胞反应的改变可影响RSV疾病的临床类型和以后支气管痉挛的发作。
Respiratory syncytial virus (RSV) is a unique respiratory pathogen. The highest incidence of serious illnesses caused by RSV is found in the first months after birth, when circulating antibodies obtained through the placenta are readily detectable. Bronchospasm is commonly associated with infection in both adults and children, suggesting that RSV-specific immune mechanisms may play a role in the etiology of the infection. Although severe diseases caused by RSV may or may not be associated with specific antibodies, little is known about cellular immunity in RSV infections. The purpose of this study was to determine the effect of cellular immunity on the type and severity of the disease caused by RSV. The results indicate that changes in T-lymphocyte responses can influence the clinical type of RSV disease and the subsequent onset of bronchospasm.