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目的:探讨肠源性内毒素对血浆 IL- 6和 IL- 8水平的影响以及在油酸所致 ARDS过程中的作用。 方法 :静脉注射油酸造成 ARDS,观察门静脉和腔静脉血内毒素及 IL- 6与 IL- 8水平的动态变化。结果:油酸注入 6 0min后门静脉和腔静脉血浆内毒素及 IL- 6和 IL- 8水平开始升高 ,并随着时间的延长而显著升高 ,各时间点与对照组相比均有显著性差异 ,同时门静脉血浆水平高于腔静脉血浆水平 (P <0 .0 5～ 0 .0 1) ;而且油酸注入 90 min和12 0 min后的水平又比 6 0 min时均有增加 (P <0 .0 1) ;内毒素水平的变化与 IL- 6和 IL- 8水平变化呈正相关关系(P <0 .0 1) 。结论 :在油酸所致 ARDS过程中有肠源性内毒素血症的发生 ,肠源性内毒素可诱导 IL- 6和 IL- 8的产生 ,参与油酸致急性肺损伤的发展和由此导致的多器官功能障碍的发生
Objective: To investigate the effect of intestinal endotoxin on the plasma levels of IL-6 and IL-8 and its role in the ARDS induced by oleic acid. Methods: ARDS was induced by intravenous injection of oleic acid, and the changes of endotoxin and the levels of IL-6 and IL-8 in portal vein and vena cava were observed. Results: The levels of plasma endotoxin and IL-6 and IL-8 in portal vein and vena cava began to increase after oleic acid injection for 60 min, and were significantly increased with time, with significant difference at each time point compared with the control group (P <0.05-0.01). Moreover, the level of oleic acid in 90 min and 120 min increased more than that in 60 min P <0.01). The changes of endotoxin levels were positively correlated with the levels of IL-6 and IL-8 (P <0.01). CONCLUSIONS: In the process of ARDS induced by oleic acid, intestinal-endotoxemia occurs. Gut-derived endotoxin induces the production of IL-6 and IL-8 and is involved in the development of acute lung injury induced by oleic acid Resulting in the occurrence of multiple organ dysfunction