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目的:探讨在急性有机磷农药中毒(AOPP)72小时后继续使用解磷定(PAM)和解磷注射液对胆碱酯酶(CHE)活性及疗效的影响.方法:83例中、重度AOPP患者随机分为对照组(43例)和治疗组(40例),均在传统综合抢救基础上应用CHE复能剂.对照组采用PAM静滴,连用3日,解磷注射液即刻肌注;治疗组PAM和解磷注射液均连用5日~7日;并用酶法测定CHE活性.结果:治疗组和对照组治愈率分别为97.5％和81.4％(P＜0.05);治疗组治疗1周内CHE活性〔(4042.25±1408.51)U/L〕及完全恢复正常时间〔(7.56±2.19)日〕均显著优于对照组〔分别为(2675.61±1472.55)U/L和(10.46±3.99)日〕,P＜0.001和P＜0.01;治疗组和对照组1周内CHE活性恢复正常率为82.5％和36.1％(P＜0.001),并发症总发生率分别为7.5％和34.9％(P＜0.01);治疗组阿托品总平均用量较对照组减少323.4MG(P＜0.01),住院时间较对照组缩短3.57日(P＜0.001).结论:酶活性的恢复与酶老化学说不符,老化酶仍存在被复活的可能;CHE复能剂的应用不宜限制时“,”Objective:To study the efficacy of pyraloxime methoiodide (PAM) and Jielin Injection(解磷注射液) used over 72 hours on acute organic phosphorus poisoning (AOPP),and their influence on cholinesterase (ChE) activity in blood.Methods:Eightythree cases with middle and serious AOPP were randomly divided into control group (43 cases )and treatment group (40 cases).Two groups were given cholinesterase reactivators in addition to use of traditionally combined treatment.In the control group,patients received PAM therapy ...