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目的观察不同剂量辛伐他汀对急性冠状动脉综合征患者外周血NF-κB及IL-6水平的影响。方法 40例急性冠状动脉综合征患者随机分为2组:10 mg辛伐他汀组(辛伐他汀10 mg/d+常规用药)和20 mg辛伐他汀组(辛伐他汀20 mg/d+常规用药)。分别测定治疗前后外周血NF-κB及IL-6的浓度。同期选取40例健康人作对照。结果急性冠状动脉综合征患者外周血NF-κB及IL-6水平测定值均高于对照组(P<0.01);两组治疗后NF-κB及IL-6的测定值均低于治疗前水平(P<0.05),20 mg辛伐他汀组与10 mg辛伐他汀组相比,降低外周血NF-κB及IL-6水平效果更加明显,二者差异有统计学意义(P<0.05)。结论辛伐他汀可明显降低急性冠状动脉综合征患者外周血NF-κB及IL-6水平,且随着剂量加大,效果更加明显。
Objective To observe the effects of different doses of simvastatin on the levels of NF-κB and IL-6 in peripheral blood of patients with acute coronary syndrome. Methods Forty patients with acute coronary syndrome were randomly divided into 2 groups: 10 mg simvastatin group (simvastatin 10 mg / d + conventional medicine) and 20 mg simvastatin group (simvastatin 20 mg / d + conventional medicine) . The levels of NF-κB and IL-6 in peripheral blood were measured before and after treatment. Forty healthy people were selected as controls during the same period. Results The levels of NF-κB and IL-6 in peripheral blood of patients with acute coronary syndrome were higher than those of the control group (P <0.01). The measured values of NF-κB and IL-6 in both groups were lower than those before treatment (P <0.05). Compared with 10 mg simvastatin group, 20 mg simvastatin group decreased the levels of NF-κB and IL-6 in peripheral blood more significantly (P <0.05). Conclusion Simvastatin can significantly reduce the levels of NF-κB and IL-6 in peripheral blood of patients with acute coronary syndrome, and the effect is more obvious with the dose increasing.