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目的:观察糖尿病患儿糖化红血蛋白(HbA1c)控制情况,了解其在糖尿病控制中的应用价值。方法:选取2009年1月1日～12月31日已确诊的糖尿病在北京儿童医院内分泌科复诊的患儿591例,检测其HbA1c水平。按性别分为男、女两组;按发育情况分为青春前期组和青春发育期组;按HbA1c的控制情况,在年龄分组的基础上分为控制理想、可接受、较差、差4组。用SPSS软件进行统计学分析。结果:男性患儿的HbA1c平均水平为(8.81±4.24)%,女性患儿的HbA1c平均水平为(8.77±3.77)%;不同性别之间HbA1c水平差异无统计学意义(P>0.05)。青春前期组的HbA1c平均水平为(7.97±1.60)%;青春发育期HbA1c平均水平为(9.28±2.47)%,两个年龄组之间差异有统计学意义(P<0.01),青春发育期HbA1c水平明显高于青春前期组。青春前期组患儿HbA1c控制较理想的比例明显高于青春发育期组(P<0.05),青春发育期组患儿HbA1c控制差的比例明显高于青春前期组(P<0.01)。结论:青春前期组的患儿因由家长监督依从性较好,HbA1c水平控制较好,青春发育期组的糖尿病患儿应加强糖尿病知识的健康教育,加强精神心理方面的治疗,制定个性化的治疗方案,减少并发症。
Objective: To observe the control of glycated red blood protein (HbA1c) in children with diabetes mellitus, and to understand its value in the control of diabetes. Methods: A total of 591 children with diagnosed diabetes mellitus who were referred to the Department of Endocrinology, Beijing Children’s Hospital from January 1 to December 31, 2009 were enrolled in this study. HbA1c levels were measured. Divided into male and female by sex; According to the development of the situation is divided into the pre-adolescent group and the pubertal group; according to the control of HbA1c, divided into age group based on the control ideal, acceptable, poor, poor 4 . Statistical analysis was performed using SPSS software. Results: The average level of HbA1c was (8.81 ± 4.24)% in male children and 8.77 ± 3.77% in female children. There was no significant difference in HbA1c between different sexes (P> 0.05). The average level of HbA1c in early adolescence was (7.97 ± 1.60)%, while the average level of HbA1c in adolescence was (9.28 ± 2.47)%, there was a significant difference between the two age groups (P <0.01) The level was significantly higher than the pre-youth group. The rate of HbA1c control in pre-adolescent group was significantly higher than that in adolescence (P <0.05). The rate of HbA1c control in adolescence was significantly higher than that in adolescence (P <0.01). Conclusion: Children in pre-adolescent group have better supervision by parents and HbA1c level is better controlled. Children with diabetes in puberty should strengthen the health education of diabetes knowledge, strengthen the psychotherapy and make personalized treatment Program to reduce complications.