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研究了消炎痛、芬布芬、酮布洛芬、萘普生及地塞米松对小白鼠腹腔渗出液白细胞数量和巨噬细胞吞噬功能的影响。在治疗剂量下,消炎痛和酮布洛芬均使渗出液中自细胞数量显著地减少(P<0.01),芬布芬和萘普生虽有减少,但无统计学意义;地塞米松亦有效地使白细胞减少(P<0.05)。所试药物均显著地抑制巨噬细胞的吞噬功能,降低吞噬率(P<0.01)和吞噬指数(P<0.01)。此外还用放射
The effects of indomethacin, fenbufen, ketoprofen, naproxen and dexamethasone on the numbers of white blood cells peritoneal exudate and the phagocytosis of macrophages in mice were studied. Both indomethacin and ketoprofen significantly decreased the number of self-infiltrating cells (P <0.01) at the therapeutic dose, while there was no significant difference between fenbufen and naproxen Leukopenia was also effectively reduced (P <0.05). The tested drugs all significantly inhibited the phagocytosis of macrophages, reduced phagocytosis rate (P <0.01) and phagocytic index (P <0.01). In addition to using radiation