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N-甲基-D-门冬氨酸受体（NMDA或NR）功能的变化与癫痫的发生和发展密切相关．本文用原位杂交技术探讨了遗传癫痫易感大鼠P77PMC惊厥后不同时间NRI亚基基因表达状况，证明：大脑皮层，海马齿状回，CA1、CA2、CA3及下丘NR1mRNA表达呈时间依赖性增高，下丘在惊厥后2h即出现NR1mRNA高表，而大脑皮层和海马各区域24h达高峰．听源性惊厥后这些区域NR1mRNA表达的上调可能与神经网络兴奋性增高及癫痫易感性的保持有关。
Changes in the function of N-methyl-D-aspartate receptor (NMDA or NR) are closely related to the occurrence and development of epilepsy. In situ hybridization technique was used to investigate the gene expression of NRI subunit at different time points after epilepsy-prone rat P77PMC seizure. The results showed that the expression of CA1, CA2, CA3 and NR1 mRNA in the inferior colliculus were time-dependent Increased, the inferior colliculus 2h after the seizures appear NR1mRNA high table, and the cerebral cortex and hippocampus reached a peak at 24 hours. Upregulation of NR1mRNA expression in these regions following auditory convulsion may be related to the increased excitability of neural networks and the maintenance of epilepsy susceptibility.