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目的了解皖南医学院第二附属医院2016年所有上报药品不良反应(ADR)发生的特点及规律,为临床安全合理用药提供参考。方法将皖南医学院第二附属医院2016年全年上报的306例ADR报告,按照发生不良反应的药品种类、严重程度、上报人员职业进行回顾性汇总、分析。结果各类药品中,中成药引发的ADR最多,达85例(27.78%)。西药制剂中抗感染药物引发的ADR最多,达75例(24.51%)。306例ADR报告中,普通ADR 207例,新的ADR 5例,严重ADR 4例。以上报人员职业分类,306例ADR中,药师上报213例(69.61%),医师上报51例(16.67%),护士上报42例(13.72%)。结论临床应重视ADR的上报工作,尤其对于严重的及新的ADR的上报。对ADR多发的药品,临床使用应更加谨慎。目前该院ADR主要由药学人员上报,医师及护士需加强上报ADR的意识。
Objective To understand the characteristics and laws of all adverse drug reactions (ADRs) reported by the Second Affiliated Hospital of Wannan Medical College in 2016, so as to provide a reference for clinical safe and rational drug use. Methods A total of 306 ADR cases reported by the Second Affiliated Hospital of Wannan Medical College in 2016 were retrospectively summarized and analyzed according to the types and severity of the drugs that had adverse reactions and the career of the reported personnel. Results All kinds of drugs, Chinese medicine induced ADR up to 85 cases (27.78%). Anti-infectives in western medicine caused the most ADR in 75 cases (24.51%). Of the 306 ADR cases, 207 were normal ADRs, 5 were newer ADRs and 4 were severe ADRs. Among the 306 ADRs, 213 (69.61%) were reported by pharmacists, 51 (16.67%) were reported by physicians, and 42 (13.72%) were reported by nurses. Conclusion Clinical reports should pay attention to the reporting of ADR, especially for serious and new reports of ADR. For ADR multiple drugs, clinical use should be more cautious. The hospital ADR is mainly reported by pharmacy staff, physicians and nurses need to strengthen the awareness of reporting to ADR.