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肝细胞生长因子 (HGF)及其受体 (c Met)在相当一部分人类肿瘤中存在高表达 ,并与恶性肿瘤发生、发展及转移密切相关。其信号转导以及它与其他细胞因子的关系正日益受到关注。丝裂原活化蛋白激酶 (MAPK)级联中MEK/ERK是细胞信号转导的重要途径 ,它可被多种炎症因子、生长因子和
Hepatocyte growth factor (HGF) and its receptor (c Met) are highly expressed in a considerable part of human tumors and are closely related to the occurrence, development and metastasis of malignant tumors. Its signal transduction and its relationship with other cytokines are receiving increasing attention. MEK / ERK is an important pathway of cell signal transduction in the mitogen-activated protein kinase (MAPK) cascade. It can be activated by a variety of inflammatory cytokines, growth factors and