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Aim:To investigate the effects of prenatal exposure to lipopolysaccharide (LPS)on blood pressure and body weight of offspring in rats.Methods:Sixteen healthy,pregnant rats were randomly divided into 2 groups.The rats in the LPS groupwere injected intraperitoneally with LPS (0.79 mg/kg) on the d 8,d 10,and d 12 ofgestation.Those in the control group were only treated with normal saline.Afterdelivery,all offspring were weighed and blood pressure was measured by the tail-cuff method once every 2 weeks from the 6th to the 24th week.In the 15th week,their food intake was weighed every day.At the end of the 24th week,the ratswere killed by decapitation.Abdominal adipose tissues were weighed,and theserum level of leptin was detected by radioimmunoassay.Results:The offspringwith prenatal LPS exposure showed increased systemic arterial pressure,heavierbody weight,elevated food intake,increased adipose tissue weight,and increasedcirculating leptin compared with the controls.Conclusion:Prenatal exposure toLPS leads to increases in blood pressure and body weight in rats.
Aim: To investigate the effects of prenatal exposure to lipopolysaccharide (LPS) on blood pressure and body weight of offspring in rats. Methods: Sixteen healthy, pregnant rats were randomly divided into 2 groups. The rats in the LPS groupwere injected intraperitoneally with LPS ( 0.79 mg / kg) on the d8, d10, and d12 ofgestation. Those in the control group were treated only with normal saline. Afterdelivery, all offspring were weighed and blood pressure was measured by the tail-cuff method once every 2 weeks from the 6th to the 24th week. the 15th week, the food intake was weighed every day. At the end of the 24th week, the ratswere killed by decapitation. Abdominal adipose tissues were weighed, and the level of leptin was detected by Results: The offspring with prenatal LPS exposure increased increased systemic arterial pressure, heavier body weight, elevated food intake, increased adipose tissue weight, and increased circulation leptin compared with the controls. Confclusion: Prenatal e xposure toLPS leads to increases in blood pressure and body weight in rats.