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目的:观察盐酸羟考酮缓释片治疗中晚期恶性肿瘤疼痛的临床效果。方法:选择杭州市肿瘤医院2017年6月至2018年8月收治的中晚期恶性肿瘤疼痛患者100例为研究对象，根据其入院顺序对其进行分组，其中观察组(50例)实施盐酸羟考酮缓释片治疗；对照组(50例)实施硫酸吗啡缓释片治疗，观察比较两组起效时间、镇痛效果以及不良反应发生情况、KPS评分。结果:观察组起效时间(0.79±0.22)h，与对照组的(2.56±1.02)h相比较，差异有统计学意义(n t＝11.995，n P<0.05)；观察组患者镇痛总有效率98.00%(49/50)，高于对照组镇痛总有效率的74.00%(37/50)(χn 2＝11.960，n P<0.05)；观察组患者不良反应发生率4.00%(2/50)，低于对照组不良反应发生率的30.00%(15/50)(χn 2＝11.977，n P<0.05)；观察组中晚期恶性肿瘤疼痛患者治疗后KPS评分(79.45±1.23)分，与对照组KPS评分[(65.34±1.92)分]相比较，差异有统计学意义(n t＝43.756，n P<0.05)。n 结论:盐酸羟考酮缓释片治疗中晚期恶性肿瘤疼痛具有显著效果，且安全性高。“,”Objective:To observe the clinical effect of oxycodone hydrochloride sustained-release tablets in the treatment of pain in advanced malignant tumors.Methods:One hundred patients with advanced malignant tumor pain admitted to Hangzhou Cancer Hospital from June 2017 to August 2018 were selected.They were grouped according to the admission order.The observation group (50 cases) implemented oxycodone hydrochloride sustained-release tablets.The control group (50 cases) was treated with morphine sulfate sustained-release tablets.The onset time, analgesic effect, adverse reaction and KPS score were compared between the two groups.Results:The onset time [(0.79±0.22)h] of the observation group was significantly shorter than that of the control group [(2.56±1.02)h](n t=11.995, n P<0.05). The total effective rate of analgesia in the observation group (98.00%) was higher than that in the control group(74.00%)(n t=11.960, n P<0.05). The incidence of adverse reactions in the observation group was 4.00%(2/50), which was lower than 30.00%(15/50) in the control group, (χn 2 =11.977, n P<0.05). The KPS score after treatment in patients with advanced malignant tumor pain in the observation group[(79.45±1.23)points] was higher than that in the control group[(65.34±1.92)points] (n t=43.756, n P<0.05).n Conclusion:Oxycodone hydrochloride sustained-release tablets have significant effects in the treatment of advanced malignant tumor pain, and it is safe.