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目的:了解新疆汉维两民族阿尔茨海默病(Alzheimer’s disease,AD)患者组与认知功能正常组(cognitively normal,ND)的牙周健康状况。方法:选择年龄为50~80岁的被确诊为AD的患者62例(AD组)与认知功能正常者63例(ND组),对所有纳入对象的牙周状况进行检查和评估。通过AD简易智力状况检查表(mini-mental state examination,MMSE)的测评结果来评估所有调查对象的认知损害程度,根据结果进一步将调查对象分为轻、中、重度。检测调查对象的牙龈指数(gingival index,GI)、菌斑指数(plaque index,PI)、探诊深度(probing depth,PD)、牙周附着水平(clinical attachment level,CAL)和出血指数(percentage of bleeding sites,BOP%)。结果:AD组所有的牙周指数均高于ND组,且随着AD的病程进展,其牙周状况愈发恶化,差异具有统计学意义(P<0.05)。根据认知损害程度分组,每组之间GI、PI、PD、CAL和BOP%均有统计学差异(P<0.05)。新疆汉族AD患者牙周状况和新疆维吾尔族AD患者牙周状况的差异无统计学意义(P>0.05)。结论:牙周健康状况随着AD的病程进展而逐渐恶化,且与个人的认知功能密切相关。
Objective: To understand the periodontal health status of Alzheimer’s disease (AD) patients and cognition normal group (ND) in Han and Uygur nationality in Xinjiang Uygur Autonomous Region. Methods: Sixty-two patients (AD group) and 63 patients with normal cognitive function (ND group) were selected from 50 to 80 years old. The periodontal status of all the patients were examined and evaluated. The degree of cognitive impairment of all subjects was assessed by the assessment results of the mini-mental state examination (MMSE), and the subjects were further classified into mild, moderate, and severe according to the results. The gingival index (GI), plaque index (PI), probing depth (PD), clinical attachment level (CAL) and percentage of bleeding bleeding sites, BOP%). Results: All periodontal indices in AD group were higher than those in ND group, and their periodontal status deteriorated with the progress of AD. The difference was statistically significant (P <0.05). According to the degree of cognitive impairment, there were significant differences in GI, PI, PD, CAL and BOP% between each group (P <0.05). There was no significant difference in periodontal status of AD patients in Xinjiang Han nationality and periodontal status of Uygur AD patients in Xinjiang (P> 0.05). Conclusion: The periodontal health condition worsens with the progress of AD, and is closely related to the cognitive function of individuals.