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目的探讨不同附子炮制品对阿霉素致急性心力衰竭的作用。方法阿霉素腹腔注射制备急性心力衰竭模型,造模后给予附子不同炮制品15d,采用生物信号采集系统记录心电图并计算心率,计算心脏系数,检测心肌钙酶、H.E.染色观察心肌组织。结果蒸附子粉制剂、炒附子粉制剂高剂量组(0.28g/ml)、低剂量组(0.07g/ml)溶液具有不同程度抗阿霉素致小鼠心衰的作用(P<0.01)。结论蒸附子粉制剂和炒附子粉制剂抗阿霉素致小鼠心衰的作用较为肯定。
Objective To investigate the effect of different aconite products on doxorubicin induced acute heart failure. Methods The model of acute heart failure was induced by adriamycin intraperitoneal injection. After the model was made, different processed products of aconite were given for 15 days. The electrocardiogram (ECG) was recorded and the heart rate was calculated. The cardiac coefficient was calculated. The myocardial calcium was detected by enzyme-linked immunosorbent assay. Results The results showed that the effects of stevioside preparations, high dose group (0.28g / ml) and low dose group (0.07g / ml) on the heart failure induced by doxorubicin in mice were significant (P <0.01). Conclusion The effect of the steaming sub-powder preparation and the aconite powder preparation on doxorubicin-induced heart failure in mice is relatively certain.