【摘 要】
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The mammalian target of rapamycin (mTOR) signaling pathway is evolutionarily conserved/mTOR can integrate and converge a wide range of signals, including intrac
【机 构】
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College of Life Sciences
论文部分内容阅读
The mammalian target of rapamycin (mTOR) signaling pathway is evolutionarily conserved/mTOR can integrate and converge a wide range of signals, including intracellular and extracellular nutrients, growth factors, energy and stress conditions, and has a crucial role in the vertebrate growth control. This review analyzed the main components and regulated factors of TOR signaling pathway, explained functions and mechanisms of mTOR during the individual growth, the development and its dynamic role, revealed its additional functions beyond the cell growth control, and finally reviewed the tissue specificity and time specificity of mTOR signaling pathway, and its regulation on sexual differentiation, tissue differentiation and organogenesis in the individual development.
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