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目的应用缬沙坦治疗老年原发性高血压患者,观察血压昼夜节律变异与血清超敏C反应蛋白(hs-CRP)的关系。方法对106例初诊轻、中度高血压患者,每日口服缬沙坦80~160 mg共12周,观察治疗前后昼夜血压节律及hs-CRP的变化。结果治疗后杓型组及逆转组hs-CRP较治疗前显著降低(P<0.05),而未逆转组无明显变化。结论有效降压及恢复血压昼夜节律,可降低hs-CRP。
Objective To investigate the relationship between circadian rhythm of blood pressure and serum hs-CRP in elderly patients with essential hypertension treated with valsartan. Methods 106 patients with newly diagnosed mild to moderate hypertension were treated with valsartan 80 ~ 160 mg daily for 12 weeks. The changes of diurnal blood pressure rhythm and hs-CRP were observed before and after treatment. Results After treatment, the hs-CRP in the dipper group and the reversed group was significantly lower than that before treatment (P <0.05), but not in the untreated group. Conclusion Effective antihypertensive and recovery of circadian rhythm of blood pressure can reduce hs-CRP.