Isolation and Characterization of Radiation-resistant Lung Cancer D6-R Cell Line

• 作 者: QI-CHUN WEI LI SHEN SHU ZHENG
• 机 构: MinistryofEducationKeyLaboratoryofCancerPreventionandIntervention,DepartmentofRadiationOncology
• 出 处: 生物医学与环境科学：英文版
• 发表日期: 2008年4期
• 关键词: 辐射敏感度 化学敏感性 细胞周期 细胞凋亡 Radiosensitivity Chemosensitivity Cell cycle Apoptosis
• 基金项目: This research was supported by a grant from Zhejiang Education Bureau （No. 20040207）, and a grant from the National Natural Science Foundation of China （No. 30470501）.y.

Objective To isolate an isogenic radioresistant cancer cell line after fractioned X-ray radiation and characterize the resistant cells. Methods D6 cells were exposed to repeated X-ray irradiation, and after a total dose of 5200 cGy in 8 fractions, a radio