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目的探讨视网膜母细胞瘤(retinoblastoma,RB)患者血清乳酸脱氢酶(lactatedehydrogenase,LDH)的变化及其对诊断的评价作用。方法 回顾性分析60例(84眼)RB患者及60例(60眼)对照组患者的临床资料。RB患者中,单眼患病者36例(右眼19例,左眼17例),双眼同时患病者24例;已行眼球摘除者17例(17眼)。应用Olympus2700全自动生化分析仪测定血清LDH水平。结果 RB组血清LDH平均水平为249.1U.L-1,LDH水平升高率为51.7%,对照组血清LDH平均水平为214.4U.L-1,LDH水平升高率为16.7%,2组比较差异有统计学意义(P<0.05);眼球未摘除组血清LDH平均水平为255.9U.L-1,LDH水平升高率为58.7%,眼球摘除组血清LDH平均水平226.8U.L-1,LDH水平升高率为21.4%,2组比较差异有统计学意义(P<0.05);眼球摘除组血清LDH平均水平及升高率与对照组相比差异均无统计学意义(均为P>0.05);单眼患者组血清LDH平均水平253.1U.L-1,LDH水平升高率为47.6%,双眼患者组血清LDH平均水平259.7U.L-1,LDH水平升高率为68.0%,差异均无统计学意义(P>0.05);D期以下(含D期)组血清LDH平均水平258.4U.L-1,LDH水平升高率为62.5%,E期组血清LDH平均水平251.1U.L-1,LDH水平升高率为53.8%,2组比较差异无统计学意义(P>0.05)。结论 血清LDH水平测定可作为RB辅助性诊断标准之一,同时也可以作为判断眼球摘除术后是否有肿瘤残留或复发的评价指标之一。
Objective To investigate the changes of serum lactate dehydrogenase (LDH) in patients with retinoblastoma (RB) and evaluate their diagnostic value. Methods The clinical data of 60 patients (84 eyes) with RB and 60 patients (60 eyes) were retrospectively analyzed. RB patients, monocular disease in 36 patients (right eye in 19 cases, 17 cases of left eye), both eyes of the same time, 24 cases of patients; already underwent enucleation in 17 cases (17 eyes). Serum LDH level was measured by Olympus2700 automatic biochemical analyzer. Results In the RB group, the average serum LDH level was 249.1 UL-1, the LDH level was 51.7% in the RB group, 214.4 UL-1 in the control group, and 16.7% in the LD group. The differences between the two groups were statistically significant (P <0.05). The average level of serum LDH was 255.9UL-1, the rate of LDH increased 58.7%, the level of serum LDH was 226.8UL-1, the rate of LDH increased 21.4% (P <0.05). There was no significant difference between the two groups in the average level of LDH and the rate of increase in the level of serum LDH (P> 0.05). The levels of serum LDH The average level of serum LDH was 253.6UL-1, the level of LDH was 47.6%, the level of serum LDH was 259.7UL-1 and the rate of LDH was 68.0% in both eyes. There was no significant difference between the two groups (P> 0.05). The average serum LDH level was 258.4UL-1, the level of LDH increased 62.5%, the level of serum LDH 251.1UL-1 in E stage was 53.8%, the level of LDH increased in group E The difference was not statistically significant (P> 0.05). Conclusions Serum LDH level can be used as one of the diagnostic criteria for RB. It can also be used as one of the evaluation indexes for determining the residual or recurrence of tumor after enucleation.