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百日咳菌苗含有脂多糖(内毒素),人和动物静脉注射内毒素后,除了可以引起已知的毒性作用外,还可以引起白细胞和血小板减少.业已证明,多粘菌素B能在体内、外中和肠杆菌和沙门氏菌的内毒素活性.多粘菌素B还能在试管内消除百日咳菌苗的内毒素反应.作者用家兔实验比较了百日咳菌苗单独注射或与多粘菌素B联合注射对白细胞、血小板计数和抗体应答的作用.将家兔分为两组:第1组(9只)分别在第1和第21天静脉注射百日咳菌苗(1.0ml/kg);第2组(8只)在相同时间注射同等剂量
Pertussis vaccine contains lipopolysaccharide (endotoxin), intravenous injection of endotoxin in humans and animals, in addition can cause known toxic effects, but also can cause leukopenia and thrombocytopenia has been demonstrated that polymyxin B can be in vivo, Endocrine and endotoxin activity of Enterobacteriaceae and Salmonella polymyxin B can also be in vitro test to eliminate pertussis bacilli endotoxin response.The author compared with rabbits pertussis vaccine injection alone or with polymyxin B The effect of co-injection on leukocyte, platelet count and antibody response The rabbits were divided into two groups: Group 1 (n = 9) received IV pertussis vaccine (1.0 ml / kg) on days 1 and 21, Group (n = 8) received the same dose at the same time