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目的探讨生长抑素与多发性梗塞痴呆之间的可能的联系。方法通过对Ｗｉｓｔａｒ大鼠颈内动脉注入血凝块栓子，制作多发性脑梗塞模型，模拟人类多发性梗塞痴呆的病理损害，研究不同脑区内生长抑素含量的变化。结果模型组与对照组相比，在水迷宫中游全程的时间显著延长，正确次数明显减少（Ｐ＜０．０１）。采用放射免疫测定法测定额叶、顶叶、海马、纹状体四个脑区内生长抑素含量，模型组比对照组生长抑素含量显著降低（分别降低７９％～８６％，Ｐ＜０．０１）。结论这种多发性梗塞模型是成功的，大鼠的学习、记忆障碍可能与重要脑区梗塞后生长抑素含量下降有关
Objective To investigate the possible relationship between somatostatin and multiple infarct dementia. Methods The model of multiple cerebral infarction was established by injecting blood clot embolus into the internal carotid artery of Wistar rats to simulate the pathological damage of human multiple infarct dementia and to study the changes of somatostatin content in different brain regions. Results Compared with the control group, the time spent in the middle of the water maze was significantly prolonged and the correct times significantly decreased (P <0.01). The contents of somatostatin in frontal lobe, parietal lobe, hippocampus and striatum were measured by radioimmunoassay. The content of somatostatin in the model group was significantly lower than that in the control group (79% -86%, P <0 .01). Conclusions This multiple infarct model is successful. Learning and memory impairment in rats may be related to the decrease of somatostatin content in patients with cerebral infarction