Clinical and Genetic Features of Familial Cold Urticaria:A Report of Three Families

• 作 者: Kai Wang Lin-Feng Li
• 机 构: Department of Dermatology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050,
• 出 处: 中华医学杂志（英文版）
• 发表日期: 2018年19期

To the Editor:Cold urticaria (CU) accounts for 1-3％ of all urticaria cases.Affected patients develop a rash and/or angioedema after physical exposure to cold agents such as cold water,air,or food.CU can be classified as an acquired or familial disorder.Familial CU (FCU) was first described in 1940.Three familial cold syndromes exist:familial delayed CU,familial cold autoinflammatory syndrome (FCAS),and familial atypical CU (FACU).[1] Here,we report three Chinese pedigrees of FCU with an autosomal dominant inheritance patt [Figure 1a].