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目的:检测肿瘤易感基因101(TSG101)在胰腺癌组织中表达水平及其与癌患者临床病理特征的关系。方法:应用免疫组织化学方法检测TSG101蛋白在胰腺癌及其对应正常胰腺组织的表达情况,并分析其在肿瘤中表达水平与患者性别、分化、临床分期及转移等临床病理资料之间的相关性。结果:TSG101在胰腺肿瘤组织中表达率为47/58(81.0%)明显高于正常胰腺组织表达率7/58(12.1%)(P<0.05),统计学分析提示TSG101在胰腺癌组织表达率明显高于正常胰腺组织(P<0.05),在高分化胰腺癌组织中表达明显强于中、低分化肿瘤组织,在转移性胰腺癌中表达率高于非转移性肿瘤组织(P<0.05),而与患者性别及临床分期间差异无统计学意义(P>0.05)。结论:TSG101在胰腺癌组织中表达与其分化程度及转移呈正相关。
Objective: To detect the expression of TSG101 in pancreatic cancer tissue and its relationship with the clinicopathological features of cancer patients. Methods: The expression of TSG101 protein in pancreatic cancer and its corresponding normal pancreatic tissue was detected by immunohistochemistry. The correlation between the expression level of TSG101 protein and the clinicopathological data such as gender, differentiation, clinical stage and metastasis was analyzed . Results: The positive rate of TSG101 in pancreatic cancer tissues was 47/58 (81.0%), which was significantly higher than that in normal pancreatic tissues (7/58) (12.1%) (P <0.05). Statistical analysis showed that the expression of TSG101 in pancreatic cancer tissues (P <0.05), and was significantly higher in well-differentiated pancreatic cancer tissues than in moderate and poorly differentiated tumor tissues, and higher in metastatic pancreatic cancer than in non-metastatic tumor tissues (P <0.05) , While there was no significant difference with the gender and clinical stage (P> 0.05). Conclusion: The expression of TSG101 in pancreatic cancer is positively correlated with its differentiation and metastasis.