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目的探讨影响乳腺癌脑转移的危险因素。方法对1997—2007年收治的乳腺癌患者进行随访,以发生脑转移的133例患者作为脑转移组,以未发生脑转移的145例患者作为对照组,就脑转移的相关因素进行对照分析。结果组织学分级为3级,肿瘤长径大于5 cm,雌激素受体(ER)阴性,人表皮生长因子受体(HER-2)阳性的乳腺癌患者容易发生脑转移;肿瘤分期,病理类型,孕激素受体(PR),腋窝淋巴结转移情况及绝经与否与脑转移无关(P>0.05)。结论组织学分级,肿瘤大小,HER-2是乳腺癌患者发生脑转移的独立危险因子;ER可能是乳腺癌脑转移的独立保护因子。
Objective To explore the risk factors affecting brain metastasis of breast cancer. Methods A total of 133 patients with brain metastases who underwent brain metastases from January 1997 to December 2007 were enrolled in the study. One hundred and forty-five patients without brain metastases were selected as the control group, and the related factors of brain metastasis were analyzed. Results The histological grade was grade 3, the tumor diameter was larger than 5 cm, the estrogen receptor (ER) negative, human epidermal growth factor receptor (HER-2) positive breast cancer patients prone to brain metastasis; tumor staging, pathological type , Progesterone receptor (PR), axillary lymph node metastasis and menopause or not with brain metastases (P> 0.05). Conclusions Histological grade, tumor size and HER-2 are independent risk factors of brain metastasis in breast cancer patients. ER may be an independent protective factor of brain metastasis in breast cancer patients.