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目的观察普罗布考对急性脑梗死患者高敏C反应蛋白和血小板功能的影响。方法56例急性脑梗死患者按入院顺序随机分为治疗组和对照组各28例。治疗组在常规治疗的基础上加普罗布考0.5g,2次/d,连续30d,并于治疗前后进行神经功能评估(NIHSS评分)与高敏C反应蛋白和血小板功能测定。结果普罗布考治疗后在神经功能改善的同时,能够降低高敏C反应蛋白并且血小板功能亦得以改善。结论普罗布考具有降低C反应蛋白和改善血小板功能的作用。
Objective To investigate the effect of probucol on the high sensitivity C-reactive protein and platelet function in patients with acute cerebral infarction. Methods Fifty-six patients with acute cerebral infarction were randomly divided into treatment group and control group according to admission order. On the basis of routine treatment, the treatment group was given probucol 0.5 g twice daily for 30 days, and neurological function evaluation (NIHSS score) and high-sensitivity C-reactive protein and platelet function were measured before and after treatment. Results After probucol treatment, neurological function was improved at the same time, high-sensitivity C-reactive protein was decreased and platelet function was also improved. Conclusion Probucol has the effect of lowering C-reactive protein and improving platelet function.