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目的探讨四种抗生素方案治疗下呼吸道感染药学经济学成本与效果。方法以2009年1月至2011年1月期间本院收治的128例下呼吸道感染患者为研究对象,随机分为4组,分别给予头孢曲松钠、舒他西林、左氧氟沙星、阿奇霉素4种抗生素治疗,运用药学经济学中最小成本分析方法对治疗方法和效果进行评价。结果四种抗生素的治疗总有效率分别为68.75%、71.88%、75.00%、68.75%,成本分别为869.37元、1125.47元、582.37元、1526.68元,成本-效果比分别为12.65、15.66、7.76、22.21,四种药物的成本-效果比之间差异具有统计学意义(P<0.05)。结论左氧氟沙星的治疗总有效率最高,且成本最低,其成本-效果比最低,具有良好的临床应用价值,是治疗下呼吸道感染的理想药物。
Objective To investigate the pharmacoeconomic costs and effects of four antibiotic regimens in the treatment of lower respiratory tract infections. Methods A total of 128 patients with lower respiratory tract infection admitted to our hospital from January 2009 to January 2011 were randomly divided into 4 groups and received ceftriaxone sodium, sultamicillin, levofloxacin and azithromycin respectively , The use of pharmacoeconomic minimum cost analysis methods to evaluate the treatment methods and effects. Results The total effective rates of the four antibiotics were 68.75%, 71.88%, 75.00% and 68.75% respectively. The cost was 869.37 yuan, 1125.47 yuan, 582.37 yuan and 1526.68 yuan respectively. The cost-effectiveness ratios were 12.65, 15.66 and 7.76, 22.21, the difference between the cost-effectiveness ratio of the four drugs was statistically significant (P <0.05). Conclusion Levofloxacin has the highest total effective rate, lowest cost, lowest cost-effect ratio and good clinical value. It is an ideal drug for the treatment of lower respiratory tract infection.