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作者利用溶菌酶作为单核吞噬细胞的免疫组化酶标,发现慢性肝炎、原发性胆汁性肝硬化及其他肝硬化的肝小叶内,枯否细胞数目明显消减。这可解释肝病时吞噬机能的障碍,其障碍表现为胶体扫描异常、对食物抗原、内毒素及抗原抗体的清除机能降低,作者认为这与肝癌的发生可能有关。枯否细胞尚能保护已被乙型肝炎病毒(HBV)感染的肝细胞,故可直接阻止HBV的致癌作用。血吸虫病可伴有肝细胞癌,但其肝癌并发率的增加也与乙型肝炎抗原增加有关,并同时伴有肝炎后性肝硬化。作者认为这与枯否细胞的减少有关。枯否细胞的减少同样见于婴儿期肝细胞癌伴有先天性肝组织结构异常的病例。在实验大鼠诱发肝癌过程中,也见到枯否细胞的逐渐减少。华支睾及麝猫后睾吸虫的感染可导致胆管癌。由于感染引起汇管区单核细胞浸润,局部的吞噬细胞减少,对恶变过程也起一定作用。
The authors used lysozyme as an immunohistochemical enzyme for mononuclear phagocytes and found that the numbers of Kupffer cells in the hepatic lobules of chronic hepatitis, primary biliary cirrhosis and other liver cirrhosis were significantly reduced. This may explain the disorder of phagocytosis when liver disease, the obstacles manifested as colloidal scanning abnormalities, the removal of food antigen, endotoxin and antigen antibodies reduced, the authors believe that this may be related to the occurrence of liver cancer. Kupffer cells can still protect Hepatitis B virus (HBV) infection of liver cells, it can directly prevent the carcinogenic effect of HBV. Schistosomiasis can be associated with hepatocellular carcinoma, but its increased incidence of hepatocellular carcinoma is also associated with an increase in hepatitis B antigens, accompanied by cirrhosis of the liver. The authors believe that this is related to the reduction of Kupffer cells. The reduction of Kupffer cells is also found in cases of infantile hepatocellular carcinoma with congenital liver tissue abnormalities. In experimental rats induced hepatocellular carcinoma, Kupffer cells are also seen gradually decreased. Infection of epididymis and Cistris sinensis can lead to cholangiocarcinoma. As the infection causes monocyte infiltration in the portal area, the local phagocytic cells decrease, which also plays a role in the malignant process.