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利多卡因(Lidocaine)有降低心肌兴奋性作用。作者为了证实利多卡因肌注防治室性期前收缩合并急性心力衰竭及心肌梗塞的效果,采用双盲法对本组共46名患有急性心肌梗塞但无充血性心力衰竭、休克或重度心律失常表现的病例进行临床对照观察。其中21例肌注利多卡因4.5mg/kg,25例给予安慰剂,均在症状出现后14小时内于三角肌部位注射给药。待出现正常的心律波并维持2分钟后即观察血压、心率的变化和抽血检查测定给药5、30、60、90、120分钟后血中药物浓度水平。测定结果表明,注射5分钟后血中药物浓度为1.81±0.22mcg/ml;10分
Lidocaine reduces myocardial excitability. In order to confirm the lidocaine intramuscular injection prevention and treatment of ventricular contraction and acute heart failure and myocardial infarction effect, double-blind method in this group of 46 patients with acute myocardial infarction without congestive heart failure, shock or severe arrhythmia The performance of the case for clinical control observation. Among them, 21 cases were intramuscularly injected lidocaine 4.5 mg / kg and 25 cases were given placebo. All patients were injected with deltoid muscle within 14 hours after the symptoms appeared. To be normal heart rate wave and maintain 2 minutes after the observation of blood pressure, heart rate changes and blood tests to determine the blood drug levels after 5,30,60,90,120 minutes. The results showed that after 5 minutes of injection of blood drug concentration of 1.81 ± 0.22mcg / ml; 10 points