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远在一个世纪以前生理学家认识到大量失血致死的原因,主要是由于循环血量的减少而不是红细胞的不足,从而奠定了急性失血后用生理盐水治疗的基础,也导致血浆代用品的发展。1896年Stdrling提出血浆蛋白质对血管内外的液体交换起着重要的作用。
More than a century ago physiologists recognized that a large number of causes of death from blood loss are mainly due to the reduction of circulating blood volume rather than the lack of red blood cells, which laid the foundation for the treatment of acute blood loss with physiological saline and also led to the development of plasma substitutes. In 1896 Stdrling proposed that plasma proteins play an important role in the exchange of fluids inside and outside the blood vessels.