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目的:探讨β-内酰胺类抗生素用药密度对G-菌耐药性变异的影响。方法:对15种β-内酰胺类抗生素进行2002～2005年用药密度统计;对4种G-菌进行连续4年耐药率变化统计,将“用药”对“耐药”的影响进行量化对比。结果:抗生素应用的选择是导致细菌耐药变异的重要因素之一。2004年亚胺培南用量增长一倍,铜绿假单胞菌(PA)对其耐药率当年增长14.3%;哌拉西林/克拉维酸和头孢哌铜/舒巴坦分别列2003年、2004年各品种用量首位,PA及产ESBLs超广谱β-内酰胺酶菌株对其耐药率均增加10%以上。结论:抗生素用药密度与细菌耐药性增长呈正相关,合理用药并控制用量可以减缓或降低耐药率的上升。
Objective: To investigate the effects of β-lactam antibiotic drug concentration on the variation of drug resistance of G-bacteria. Methods: Fifteen kinds of β-lactam antibiotics were used to calculate the drug density from 2002 to 2005. Four kinds of G-bacteria were continuously changed for 4 years. The drug resistance of " The impact of quantitative comparison. Results: The choice of antibiotics is one of the important factors leading to the variation of bacterial resistance. In 2004, the dosage of imipenem doubled and the rate of drug resistance of Pseudomonas aeruginosa (PA) increased by 14.3% in the same year; the piperacillin / clavulanic acid and cefoperazone / sulbactam were listed in 2003, 2004 The amount of all varieties in the first year, PA and ESBLs ESBLs-producing strains of resistant strains were increased by more than 10%. Conclusion: The antibiotic drug density is positively correlated with the increase of bacterial resistance. Rational drug use and dosage control can slow or reduce the increase of drug resistance.