,Association of vitamin D receptor and estrogen receptor-α gene polymorphism with peak bone mass and

• 作 者: Yue-juan QIN Zhen-lin ZHANG Qi-ren HUANG Jin-wei HE Yun-qiu HU Qi ZHOU Jing-hui LU Miao LI Yu-juan LIU
• 机 构: Center for Preventing and Treating Osteoporosis,Osteoporosis Research Unit,Shanghai JiaoTong Univers
• 出 处: 中国药理学报（英文版）
• 发表日期: 2004年4期
• 关键词: bone density bone remodeling calcitriol receptors estrogen receptors restriction

AIM: To investigate if vitamin D receptor (VDR) gene Apa I polymorphism and estrogen receptor-α (ER-α) gene Pvu II, Xba I polymorphisms are related to bone mineral density (BMD), bone mineral content (BMC) and bone size in premenopausal Chinese women. METHODS: The VDR Apa I genotype and ER-α Pvu II, Xba I genotype were determined by PCR-restriction fragment length polymorphism (RFLP) in 493 unrelated healthy women aged 20-40 years of Hah nationality in Shanghai city. BMD (g/cm2), BMC (g), and bone areal size (BAS, cm2) at lumbar spine 1-4 (L1-4) and proximal femur (femoral neck, trochanter and Ward’s triangle) were measured by duel-energy X-ray absorptionmetry. RESULTS: All allele frequencies did not deviate from Hardy-Weinberg equilibrium. After phenotypes were adjusted for age, height, and weight, a significant association was found between VDR Apa I genotype and BMC variation at L1-4 and Ward’s triangle (P<0.05), but not in BMD or BAS at lumbar spine and proximal femur.ER-α Pvu II, Xba I genotype was not related to BMC, BMD, and BAS at all sites. CONCLUSION: The study suggested that Apa I polymorphism in VDR gene may influence on attainment and maintenance of peak bone mass in premenopausal Chinese women.