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血管紧张素转换酶(简称ACE)义称肽基-二肽水解酶、肽基-羧基肽酶或称血管紧张素Ⅰ转换酶、激肽酶Ⅱ(KioioaseⅡ)。ACE作用于由血清中的肾素基质产生的血管紧张素Ⅰ,将其肽键的羧基末端的两个氨基酸(组氨酸、亮氨酸)切断,形成八肽的血管紧张素Ⅱ。另外,ACE还可作用于徐缓激肽连续切断其羧基末端的丙氨酸-精氨酸链和丝氨酸-脯氨酸链。血管紧张索Ⅱ具有收缩血管作用,而徐缓激从则有扩
Angiotensin converting enzyme (referred to as ACE) known as peptidyl-dipeptide hydrolase, peptidyl-carboxypeptidase or angiotensin I converting enzyme, kininase Ⅱ (Kioioase Ⅱ). ACE acts on angiotensin I produced by the renin matrix in serum and cleaves the two amino acids (histidine and leucine) at the carboxyl terminus of its peptide bond to form octapeptide angiotensin II. In addition, ACE can also act on Xu bradykinin continuous cut off its carboxyl terminal alanine - arginine and serine - proline chain. Angiotensin II has a vasoconstrictive effect, while the slow release from the bradycardia