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目的：研究蒙汉族间甲硝唑唾液药代动力学是否存在民族差异。方法：８名蒙古族健康志愿者（男５人，女３人）及８名汉族健康志愿者（男３人，女５人）单次口服甲硝唑０６ｇ。采用ＨＰＬＣ苦味酸内标法测定甲硝唑唾液浓度及３Ｐ８７软件计算药代动力学参数。结果：甲硝唑唾液浓度药时曲线符合一室开放模型，两组药时曲线近似。蒙古族组的Ｃｍａｘ（１０６０ｍｇ／Ｌ），Ｔｍａｘ（１８６ｈ）及ＡＵＣ（１９１３８ｍｇ／Ｌ·ｈ）与汉族组（分别为１１３２ｍｇ／Ｌ，１６０ｈ及１８５３８ｍｇ／Ｌ·ｈ）无显著差异（Ｐ＞００５）。蒙古族组的Ｔ１２ｋｅ（１０８０ｈ）虽较汉族组（９７３ｈ）稍长，但无统计学差异（Ｐ＞００５）。结论：甲硝唑唾液药代动力学在蒙汉族间无明显差异。
Objective: To investigate whether there are ethnic differences in the pharmacokinetics of metronidazole saliva between Mongolian and Han nationality. Methods: Eight Mongolian healthy volunteers (5 males and 3 females) and 8 healthy Han volunteers (3 males and 5 females) were given a single oral metronidazole 0.6 g. The concentration of metronidazole saliva was determined by HPLC picric acid internal standard method and 3P87 software was used to calculate the pharmacokinetic parameters. Results: The curve of metronidazole saliva concentration conformed to the one-compartment open model. In the Mongolian group, Cmax (1060mg / L), Tmax (1.86h), AUC (19138mg / L · h) and Han nationality (1132mg / L, 160h and 18538mg / L · h) was no significant difference (P> 005). Although the T12ke (1080h) in the Mongolian group was slightly longer than that in the Han nationality (973h), there was no significant difference (P> 005). Conclusion: The pharmacokinetics of metronidazole saliva have no significant difference between Mongolian and Han nationality.